Motif ID: TFAP2{A,C}.p2

Z-value: 5.591


Transcription factors associated with TFAP2{A,C}.p2:

Gene SymbolEntrez IDGene Name
TFAP2A 7020 transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFAP2C 7022 transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TFAP2Achr6_-_10523424-0.371.6e-01Click!
TFAP2Cchr20_+_54637714-0.243.7e-01Click!


Activity profile for motif TFAP2{A,C}.p2.

activity profile for motif TFAP2{A,C}.p2


Sorted Z-values histogram for motif TFAP2{A,C}.p2

Sorted Z-values for motif TFAP2{A,C}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TFAP2{A,C}.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_136673534 9.509 COL5A1
collagen, type V, alpha 1
chr9_+_136673464 7.949 NM_000093
 COL5A1
collagen, type V, alpha 1
chr15_-_46724360 7.556 FBN1
fibrillin 1
chr17_+_56832255 7.085 TBX2
T-box 2
chr17_+_56831951 6.969 NM_005994
 TBX2
T-box 2
chr3_-_126257425 6.423 NM_020733
 HEG1
HEG homolog 1 (zebrafish)
chr15_+_64782468 6.277 SMAD6
SMAD family member 6
chr14_+_92049396 5.877 NM_024832
 RIN3
Ras and Rab interactor 3
chr2_+_85834111 5.808 NM_032827
 ATOH8
atonal homolog 8 (Drosophila)
chr2_+_36436873 5.576 NM_016441
 CRIM1
cysteine rich transmembrane BMP regulator 1 (chordin-like)
chr6_+_107917965 5.454 NM_018013
 SOBP
sine oculis binding protein homolog (Drosophila)
chr20_+_44771532 5.450 NM_030777
 SLC2A10
solute carrier family 2 (facilitated glucose transporter), member 10
chr2_+_159533329 5.443 NM_001145909
NM_033394
 TANC1

tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1

chr9_-_83493415 5.288 NM_005077
 TLE1
transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
chr14_-_24588916 5.207 NM_014178
 STXBP6
syntaxin binding protein 6 (amisyn)
chr3_-_130807865 5.169 NM_015103
 PLXND1
plexin D1
chr19_+_39664706 5.167 NM_001080436
 WTIP
Wilms tumor 1 interacting protein
chr5_+_92946348 5.088 NR2F1
nuclear receptor subfamily 2, group F, member 1
chr15_-_53667800 4.989 PYGO1
pygopus homolog 1 (Drosophila)
chr19_+_15079141 4.972 NM_033025
 SYDE1
synapse defective 1, Rho GTPase, homolog 1 (C. elegans)

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 118 entries
enrichment   p-value GO term description
1.48 2.14e-02 GO:0010639 negative regulation of organelle organization
1.44 3.18e-02 GO:0000082 G1/S transition of mitotic cell cycle
1.43 1.02e-06 GO:0051325 interphase
1.43 1.39e-06 GO:0051329 interphase of mitotic cell cycle
1.40 1.48e-03 GO:0051129 negative regulation of cellular component organization
1.39 8.43e-04 GO:0030036 actin cytoskeleton organization
1.38 3.28e-03 GO:0046578 regulation of Ras protein signal transduction
1.37 1.12e-02 GO:0071156 regulation of cell cycle arrest
1.36 4.03e-02 GO:0000075 cell cycle checkpoint
1.35 2.73e-03 GO:0030029 actin filament-based process
1.34 1.12e-03 GO:0033043 regulation of organelle organization
1.33 6.81e-03 GO:0031401 positive regulation of protein modification process
1.32 7.95e-04 GO:0007264 small GTPase mediated signal transduction
1.32 1.48e-03 GO:0044419 interspecies interaction between organisms
1.31 2.27e-06 GO:0000278 mitotic cell cycle
1.31 1.01e-03 GO:0051247 positive regulation of protein metabolic process
1.31 1.41e-03 GO:0032270 positive regulation of cellular protein metabolic process
1.31 4.74e-03 GO:0010564 regulation of cell cycle process
1.31 8.60e-03 GO:0009894 regulation of catabolic process
1.31 3.91e-02 GO:0031329 regulation of cellular catabolic process

Gene overrepresentation in compartment category:

Showing 1 to 20 of 36 entries
enrichment   p-value GO term description
1.46 2.81e-03 GO:0031301 integral to organelle membrane
1.42 8.58e-04 GO:0031252 cell leading edge
1.39 1.75e-02 GO:0031300 intrinsic to organelle membrane
1.39 4.37e-02 GO:0000151 ubiquitin ligase complex
1.31 3.13e-03 GO:0015629 actin cytoskeleton
1.31 2.54e-02 GO:0005635 nuclear envelope
1.24 6.08e-03 GO:0044427 chromosomal part
1.23 1.00e-17 GO:0005829 cytosol
1.23 3.38e-03 GO:0005694 chromosome
1.20 1.44e-12 GO:0044428 nuclear part
1.19 3.59e-09 GO:0031981 nuclear lumen
1.18 1.03e-05 GO:0005654 nucleoplasm
1.17 6.94e-10 GO:0070013 intracellular organelle lumen
1.17 1.57e-09 GO:0031974 membrane-enclosed lumen
1.17 3.04e-03 GO:0005794 Golgi apparatus
1.17 4.86e-02 GO:0031967 organelle envelope
1.16 4.04e-09 GO:0043233 organelle lumen
1.16 9.05e-06 GO:0012505 endomembrane system
1.13 1.22e-22 GO:0044444 cytoplasmic part
1.13 9.65e-18 GO:0044422 organelle part

Gene overrepresentation in function category:

Showing 1 to 20 of 31 entries
enrichment   p-value GO term description
2.21 4.67e-03 GO:0004675 transmembrane receptor protein serine/threonine kinase activity
2.19 2.27e-02 GO:0005024 transforming growth factor beta receptor activity
1.86 7.12e-04 GO:0046332 SMAD binding
1.39 2.50e-02 GO:0005085 guanyl-nucleotide exchange factor activity
1.36 2.31e-04 GO:0005083 small GTPase regulator activity
1.33 4.75e-06 GO:0004674 protein serine/threonine kinase activity
1.32 4.57e-06 GO:0030695 GTPase regulator activity
1.31 7.84e-06 GO:0060589 nucleoside-triphosphatase regulator activity
1.29 9.41e-03 GO:0003779 actin binding
1.27 1.65e-04 GO:0008092 cytoskeletal protein binding
1.26 1.32e-06 GO:0019899 enzyme binding
1.24 9.58e-04 GO:0004672 protein kinase activity
1.22 2.48e-05 GO:0016772 transferase activity, transferring phosphorus-containing groups
1.22 4.83e-04 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.21 4.19e-04 GO:0016301 kinase activity
1.19 1.60e-09 GO:0035639 purine ribonucleoside triphosphate binding
1.19 2.41e-09 GO:0017076 purine nucleotide binding
1.18 5.55e-09 GO:0032553 ribonucleotide binding
1.18 5.55e-09 GO:0032555 purine ribonucleotide binding
1.18 1.02e-06 GO:0030554 adenyl nucleotide binding